Malignant Prolactinoma Discovered by D2 Receptor Imaging

CLINICAL CASE SEMINAR Malignant Prolactinoma Discovered by D2 Receptor Imaging

Malignant prolactinoma: case report and review of the literature.

Pituitary carcinomas are extremely rare. In general, the initial clinical, biochemical, and histological characteristics are of minimal utility in distinguishing benign adenomas from pituitary carcinomas. We describe a 63-year-old woman with a macroprolactinoma, who presented with diplopia and blurred vision. This unusual initial presentation and the subsequent aggressive clinical course, with ...

PET imaging of dopamine-D2 receptor internalization in schizophrenia

This corrects the article DOI: 10.1038/mp.2017.107.

Resistance to dopamine agonists in prolactinoma is correlated with reduction of dopamine D2 receptor long isoform mRNA levels.

OBJECTIVE Dopamine agonists normalize prolactin (PRL) levels and reduce tumour size in responsive prolactinoma. However, several cases have shown resistance to dopamine agonists upon initial treatment. Infrequently, prolactinoma initially responds, but then becomes refractory to prolonged treatment (secondary resistance). We investigated the possible mechanisms of resistance to dopamine agonist...

Novel estrogen receptor discovered.

T here are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins’ subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner within the three-dimensional confines of the nuclear volume. In this review we describe recent advances ...